IOAN MARGINEAN

EDUCATION
2006PhD, George Washington University (Washington DC, USA), mentor: Professor Akos Vertes, thesis: From chaotic cone pulsation to ion evaporation in electrosprays.
19973 month Tempus scholarship at CTI Centre for Chemistry (Liverpool, UK) in Computer Aided Learning. Specific learning application for Analytical Spectrometry
1995-1997Technical University (Cluj-Napoca, Romania), Faculty of Automatic Control and Computer Science (interrupted to take a position at Babes-Bolyai University)
1990-1995Babes-Bolyai University (Cluj-Napoca, Romania), Department of Chemistry, mentor: Prof. Emil A. Cordos, undergraduate research topic: Computer Controlled Atomic Emission Spectrometer
APPOINTMENTS
2013-presentAssistant Professor of Forensic Sciences, George Washington University (Washington, DC)
2009-2013Senior research scientist, Pacific Northwest National Laboratory (Richland, WA)
2006-2009Postdoctoral researcher, Pacific Northwest National Laboratory (Richland, WA), mentor: Prof. Richard D. Smith
2001-2006Research assistant, George Washington University (Washington, DC), mentor: Prof. Akos Vertes
1997-2000Teaching assistant, Babes-Bolyai University, Department of Chemistry, Analytical Chemistry Division (Cluj-Napoca, Romania)
1995-1998Research assistant, Research Center for Analytical Instrumentation (Cluj-Napoca, Romania)
1993-1995Research student, Research Center for Analytical Instrumentation (Cluj-Napoca, Romania)
AFFILIATIONS
  • American Chemical Society
  • American Society for Mass Spectrometry
AWARDS
PUBLICATIONS
  1. Ioan Marginean, Keqi Tang, Richard D. Smith, Ryan T. Kelly, Picoelectrospray Ionization Mass Spectrometry Using Narrow-Bore Chemically Etched Emitters, J. Am. Soc. Mass Spectrom. 2013, in press.
  2. Ioan Marginean, Scott R. Kronewitter, Ronald J. Moore, Gordon W. Slysz, Matthew E. Monroe, Gordon A. Anderson, Keqi Tang, Richard D. Smith, Improving N-Glycan Coverage using HPLC-MS with Electrospray Ionization at Sub-ambient Pressure, Anal. Chem. 2012, 84 (21): 9208-9213.
  3. Keqi Tang, Jason S. Page, Ioan Marginean, Ryan T. Kelly, Richard D. Smith, Improving liquid chromatography-mass spectrometry sensitivity using a subambient pressure ionization with nanoelectrospray (SPIN) interface, J. Am. Soc. Mass Spectrom. 2011, 22 (8): 1318-1325.
  4. Ioan Marginean, Jason S. Page, Aleksey V. Tolmachev, Keqi Tang, Richard D. Smith, Achieving 50% ionization efficiency in subambient pressure ionization with nanoelectrospray, Anal. Chem. 2010, 88 (22): 9344-9349.
  5. Jason S. Page, Ioan Marginean, Ryan T. Kelly, Keqi Tang, Richard D. Smith, Biases in ion transmission through an electrospray ionization-mass spectrometry capillary inlet, J. Am. Soc. Mass Spectrom. 2009, 20 (12): 2265–2272.
  6. Ioan Marginean, Jason S. Page, Ryan T. Kelly, Keqi Tang, Richard D. Smith, Effect of pressure on electrospray characteristics, Appl. Phys. Lett. 2009, 95 (18): 184103.
  7. Ryan T. Kelly, Jason S. Page, Ioan Marginean, Keqi Tang, Richard D. Smith, Dilution-free analysis from picoliter droplets by nano-electrospray ionization mass spectrometry, Angew. Chem. Int. Ed. 2009, 48 (37): 6832-6835.
  8. Ioan Marginean, Ryan T. Kelly, Ronald J. Moore, David C. Prior, Brian L. LaMarche, Keqi Tang, Richard D. Smith, Selection of the optimum electrospray voltage for gradient elution LC-MS measurements, J. Am. Soc. Mass. Spectrom. 2009, 20 (4): 682–688.
  9. Ioan Marginean, Ryan T. Kelly, David C. Prior, Brian L. LaMarche, Keqi Tang, Richard D. Smith, Analytical characterization of the electrospray ion source in the nanoflow regime, Anal. Chem. 2008, 80 (17): 6573-6579.
  10. Ryan T. Kelly, Jason S. Page, Ioan Marginean, Keqi Tang, Richard D. Smith, Nanoelectrospray emitter arrays providing interemitter electric field uniformity, Anal. Chem. 2008, 80 (14): 5660–5665.
  11. Guanghong Luo, Ioan Marginean, Louise Ye, Akos Vertes, Competing ion decomposition channels in matrix-assisted laser desorption ionization, J. Phys. Chem. B 2008, 112 (23): 6952-6956.
  12. Ioan Marginean, Ryan T. Kelly, Jason S. Page, Keqi Tang, Richard D. Smith, Electrospray characteristic curves: In pursuit of improved performance in the nanoflow regime, Anal. Chem. 2007, 79 (21): 8030-8036.
  13. Ioan Marginean, Peter Nemes, Akos Vertes, Astable regime in electrosprays, Phys. Rev. E 2007, 76 (2): 026320.
  14. Peter Nemes, Ioan Marginean, Akos Vertes, Spraying mode effect on droplet formation and ion chemistry in electrosprays, Anal. Chem. 2007, 79 (8): 3105-3116.
  15. Ioan Marginean, Peter Nemes, Akos Vertes, Order-chaos-order transitions in electrosprays: the electrified dripping faucet, Phys. Rev. Lett. 2006, 97 (6): 064502. Featured in Virt. J. Nanoscale Sci. Tech. 2006, 14 and Virt. J. Biol. Phys. Res. 2006, 15
  16. Ioan Marginean, Peter Nemes, Lida Parvin, Akos Vertes, How much charge is there on a pulsating Taylor cone?, Appl. Phys. Lett. 2006, 89 (6): 064104.
  17. Ioan Marginean, Vasiliy Znamenskiy, Akos Vertes, Charge reduction in electrosprays: slender nanojets as intermediates, J. Phys. Chem. B 2006, 110 (12): 6397-6404.
  18. Emil A. Cordos, Tiberiu Frentiu, Michaela Ponta, Ioan Marginean, Bela Abraham, Cecilia Roman, Distribution study of inorganic arsenic (III) and (V) species in soil and their mobility in the area of Baia-Mare, Romania, Chem. Spec. Bioavail. 2006, 18 (1): 11-25.
  19. Emil A. Cordos, Tiberiu Frentiu, Michaela Ponta, Bela Abraham, Ioan Marginean, Optimisation of analytical parameters in inorganic arsenic (III and V) speciation by hydride generation using L-cysteine as prereducing agent in diluted HCl medium, Chem. Spec. Bioavail. 2006, 18 (1): 1-9.
  20. Akos Vertes, Guanghong Luo, Louise Ye, Yong Chen, Ioan Marginean, Laser pulse length dependence of internal energy transfer in UV-MALDI-MS, Appl. Phys. A 2004, 79 (4-6): 823-825.
  21. Ioan Marginean, Lida Parvin, Linda Heffernan, Akos Vertes, Flexing the electrified meniscus: the birth of a jet in electrosprays, Anal. Chem. 2004, 76 (14): 4202-4207.
  22. Tiberiu Frentiu, Michaela Ponta, Sorin D. Anghel, Alpar Simon, Ioan Marginean, Emil A. Cordos, Statistical evaluation of Cu, Mn and Zn determinations in biological samples by radiofrequency capacitively coupled plasma atomic emission spectrometry using the Bland and Altman test, Microchim. Acta 2003, 143 (4): 245-254.
  23. Vasiliy Znamenskiy, Ioan Marginean, Akos Vertes, Solvated ion evaporation from charged water nanodroplets, J. Phys. Chem. A 2003, 107 (38): 7406-7412.
  24. Guanghong Luo, Ioan Marginean, Akos Vertes, Internal energy of ions generated by matrix-assisted laser desorption ionization, Anal. Chem. 2002, 74 (24): 6185-6190.
BOOK CHAPTERS
  1. Keqi Tang, Jason S. Page, Ryan T. Kelly, Ioan Marginean, Electrospray Ionisation in Mass Spectrometry, in Encyclopedia of Spectroscopy and Spectrometry 2nd Edition. J. C. Lindon, G. E. Tranter, D. W. Koppenaal (Eds) Elsevier: Oxford, UK, 2010: 467-474.
PROCEEDINGS
  1. Ioan Marginean, Scott Kronewitter, Ron Moore, Matthew E. Monroe, Keqi Tang, Richard D. Smith, "Increasing analyte ion charge states via Sub-ambient Pressure Ionization with Nanoelectrospray", 60th ASMS Conference on Mass Spectrometry, Vancouver, BC, May 20 - 24, 2012.
  2. Scott R. Kronewitter, Ioan Marginean, Erin S. Baker, Daniel J. Orton, Gordon W. Slysz, Heather M. Brewer, Thomas L. Fillmore, Kevin L. Crowell, Brian L. LaMarche, Yehia M. Ibrahim, Matthew E. Monroe, Carrie D. Nicora, David G. Camp II, Gordon A. Anderson, Ronald J. Moore, Richard D. Smith, "Global Serum Deglycosylation in High Throughput LC-MS Glycomics: Enhanced Data Clarity via Improved Enzyme Release, Reduction, NanoLC, and IMS-QTOF", 60th ASMS Conference on Mass Spectrometry, Vancouver, BC, May 20 - 24, 2012.
  3. Yuqian Gao, Tujin Shi, Ioan Marginean, Weijun Qian, Richard D. Smith, Keqi Tang, "Achieving higher sensitivity for LC-SRM MS quantification of low abundance biomarkers using advanced ESI source and interface technologies", 60th ASMS Conference on Mass Spectrometry, Vancouver, BC, May 20 - 24, 2012.
  4. Keqi Tang, Ioan Marginean, Jason S. Page, Ryan T. Kelly, Richard D. Smith, "Improving LC-MS sensitivity by using a subambient pressure nanoESI source", 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5 - 9, 2011.
  5. Keqi Tang, Ioan Marginean, Ryan T. Kelly, Richard D. Smith, "Advancing ESI-MS Interface Technologies for High Sensitivity Proteomics", Pittcon Conference and Expo, Atlanta, GA, March 13 - 18, 2011.
  6. Ioan Marginean, Jason Page, Aleksey Tolmachev, Keqi Tang, Richard D. Smith, "Achieving >50% ion utilization efficiency in ESI-MS", 58th ASMS Conference on Mass Spectrometry, Salt Lake City, UT, May 23 - 27, 2010.
  7. Brent Dixon, Jason S. Page, Ioan Marginean, Nitin Agrawal, Ryan T. Kelly, Keqi Tang, Richard D. Smith, "Exploration and developments in nano-electrospray ionization sources operating at atmospheric and sub-atmospheric pressure", 58th ASMS Conference on Mass Spectrometry, Salt Lake City, UT, May 23 - 27, 2010.
  8. Jason S Page, Ryan T Kelly, Ioan Marginean, Keqi Tang, Richard D. Smith, "Increasing MS sensitivity by overcoming ion transmission biases and inefficiencies in the ESI MS interface", Pittcon Conference and Expo, Orlando, FL, February 28 - March 5, 2010.
  9. Jason Page, Ioan Marginean, Ryan Kelly, Keqi Tang, Richard D. Smith, "Towards total ion utilization: Electrospray ionization in a sub-ambient pressure environment for high sensitivity mass spectrometry", 57th ASMS Conference on Mass Spectrometry, Philadelphia, PA, May 31 - June 4, 2009.
  10. Ioan Marginean, Ryan Kelly, Ronald Moore, David Prior, Brian L LaMarche, Keqi Tang, Richard D. Smith, "Performance of the electrospray ion source during reversed-phase LC-MS analyses", 57th ASMS Conference on Mass Spectrometry, Philadelphia, PA, May 31 - June 4, 2009.
  11. Keqi Tang, Jason Page, Ryan Kelly, Ioan Marginean, Erin Baker, Richard D. Smith, "Bridging the micro-flow LC and nano-flow ESI: An emitter array ion source for sensitive and quantitative LC-MS analyses", 57th ASMS Conference on Mass Spectrometry, Philadelphia, PA, May 31 - June 4, 2009.
  12. Ioan Marginean, Ryan T. Kelly, David C. Prior, Brian L. LaMarche, Keqi Tang, Richard D. Smith, (31) "Is a Cone-Jet Electrospray the Holy Grail of ESI-MS?", 35th Annual FACSS Meeting, Reno, NV, September 28 - October 2, 2008.
  13. Akos Vertes, Peter Nemes, Ioan Marginean, Samita Goyal, (42) "From spray stability to ion formation: contorted menisci and ion chemistry in electrosprays", 34th Annual FACSS Meeting, Memphis, TN, October 14-18, 2007.
  14. Richard D Smith, Keqi Tang, Mikhail E Belov, Jason S Page, Ryan T Kelly, Brian H Clowers, Yehia M Ibrahim, Erin M Baker, Ioan Marginean, "The Road to Proteomics Perfection: New Developments Improving Throughput, Sensitivity, and Data Quality", HUPO 6th Annual World Congress, Seoul, Korea, October 6-10, 2007.
  15. Richard D. Smith, Keqi Tang, Mikhail E. Belov, Jason S. Page, Ryan T. Kelly, Ioan Marginean, "Advancing the sensitivity, quality, and throughput of mass spectrometry measurements for highly complex biological mixtures", 234th ACS National Meeting, Boston, MA, August 19-23, 2007.
  16. Jason S. Page, Ryan T. Kelly, Ioan Marginean, Keqi Tang, Richard D. Smith, "Increasing the ionization and transmission efficiency in electrospray ionization mass spectrometry using an array of emitters and a multi-inlet interface", 234th ACS National Meeting, Boston, MA, August 19-23, 2007.
  17. Ioan Marginean, Ryan T. Kelly, Jason S. Page, Keqi Tang, Richard D. Smith, "Toward a stable electrospray", 55th ASMS Conference on Mass Spectrometry, Indianapolis, IN, June 3-7, 2007.
  18. Peter Nemes, Ioan Marginean, Samita Goyal, Akos Vertes, "Regime-dependent ion production in electrosprays: the drop, the whip and the jet", 25th Informal Meeting on Mass Spectrometry, Nyíregyháza-Sóstó, Hungary, May 6-10, 2007.
  19. Peter Nemes, Ioan Marginean, Akos Vertes, "Ion chemistry and conformation change with spraying modes in electrosprays", 33rd Annual FACSS Meeting, Lake Buena Vista, FL, September 24-28, 2006.
  20. Peter Nemes, Ioan Marginean, Akos Vertes, "Electrosprays: Chaos and Chemistry in the Electrified Dripping Faucet", Desorption, Athens, Greece, September 3-7, 2006.
  21. Ioan Marginean, Peter Nemes, Akos Vertes, "Chaotic transitions between electrospray regimes", 54th ASMS Conference on Mass Spectrometry, Seattle, WA, May 28 – June 1, 2006.
  22. Peter Nemes, Ioan Marginean, Akos Vertes, "Correlation between spraying modes and ion chemistry in electrosprays", 54th ASMS Conference on Mass Spectrometry, Seattle, WA, May 28 – June 1, 2006.
  23. Akos Vertes, Ioan Marginean, Frederick J. Cox, Murray V. Johnston, "Research collaboration and teaching through cyber-enabled mass spectrometry", 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006.
  24. Ioan Marginean, Peter Nemes, Akos Vertes, (62) "Mode changes in electrosprays: needle geometry and wettability effects", 32nd Annual FACSS Meeting, Quebec City, QB, October 9-13, 2005.
  25. Ioan Marginean, Peter Nemes, Akos Vertes, "Chaos–Order Transitions of Pulsating Taylor Cones in Electrosprays", 230th ACS National Meeting, Washington, DC, August 28 - September 1, 2005.
  26. Akos Vertes, Yong Chen, Guanghong Luo, Ioan Marginean, Louise Ye, "Laser Pulse Length Dependence of Ionization Processes and Internal Energy Transfer in UV-MALDI-MS", The 7th International Conference on Laser Ablation, Hersonissos, Crete, Greece, October 5-10, 2003.
  27. Ioan Marginean, Vasiliy Znamenskiy, Akos Vertes, "Charge reduction in electrospray: charged nanojets as intermediates", 51st ASMS Conference on Mass Spectrometry, Montreal, QB, June 8-12, 2003.
  28. Guanghong Luo, Ioan Marginean, Louise Ye, Akos Vertes, "Laser pulse length dependence of internal energy transfer in MALDI", 51st ASMS Conference on Mass Spectrometry, Montreal, QB, June 8-12, 2003.
  29. Lida Parvin, Linda Heffernan, Ioan Marginean, Akos Vertes, "Direct link between current oscillations and Taylor cone instabilities in electrospray", 51st ASMS Conference on Mass Spectrometry, Montreal, QB, June 8-12, 2003.
  30. Ioan Marginean, Guanghong Luo, Louise Ye, Akos Vertes, "Internal energy of MALDI-generated ions", 225th ACS National Meeting, New Orleans, LA, March 23-27, 2003.
  31. Akos Vertes, Ioan Marginean, Vasiliy Znamenskiy, "Structure, morphology and dynamics of charged nanodroplets", 225th ACS National Meeting, New Orleans, LA, March 23-27, 2003.
  32. Guanghong Luo, Ioan Marginean, Akos Vertes, (194) "Internal energy of ions generated by matrix-assisted laser desorption ionization", 29th Annual FACSS Meeting, Providence, RI, October 13-17, 2002.
  33. Akos Vertes, Vasiliy Znamenskiy, Ioan Marginean, "Large ions in small droplets: structure, morphology and dynamics", Desorption 2002, Estes Park, Colorado, September 1-5, 2002.
  34. Guanghong Luo, Ioan Marginean, Akos Vertes, "Internal energy of molecular thermometer ions generated by MALDI", 50th ASMS Conference on Mass Spectrometry, Orlando, FL, June 2-6, 2002.
  35. Ioan Marginean, Akos Vertes, Frederick J. Cox, Murray V. Johnston, "Remote MALDI-MS experiments from the classroom", 50th ASMS Conference on Mass Spectrometry, Orlando, FL, June 2-6, 2002.
  36. Ioan Marginean, Alpar Fodor, Horia Mioscu, Emil A. Cordos, "Using LabVIEW's multitasking feature for measuring GFAAS signals", CC'97 Conferentia Chemometrica, Budapest, Hungary, August 21-23, 1997.